Target-specific DSI at TRN synapses. Target-specific DSI at TRN synapses. At time t = 0, neurons were depolarized from −70 to 0 mV for 5 s. A, B, Average responses of representative experiments are shown before (Δt = −3 s) and 6 and 33 s after the beginning of the postsynaptic depolarization for control conditions (top) and in the presence of the CB1R antagonist AM251 (5 μm, bottom) for TRN (A) and VB neurons (B). C, D, Summaries of the DSI time course are shown for control conditions (closed symbols, n = 8) and in the presence of AM251 (5 μm, open symbols, n = 8) for TRN (C) and VB neurons (D). Data are expressed as mean ± SEM. Yan-Gang Sun et al. J. Neurosci. 2011;31:9222-9230 ©2011 by Society for Neuroscience