FILM immunohistochemical protein signature is significantly associated with poor survival. FILM immunohistochemical protein signature is significantly.

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FILM immunohistochemical protein signature is significantly associated with poor survival. FILM immunohistochemical protein signature is significantly associated with poor survival. A, representative photomicrographs depicting immunohistochemical expression of the indicated antigens in FFPE histologic tissue specimens of lung adenocarcinoma. B, following analysis of FILM protein expression by immunohistochemistry, lung adenocarcinomas (n = 156) and SCCs (n = 79) were dichotomized into groups with high (red) versus low (blue) expression of FILM protein based on the combined immunoreactivity score of the antigens. For further validation of the FILM protein prognostic signature, all stages (n = 156; C) or stage-I (n = 123; D) lung adenocarcinomas were clustered following median-centering of the antigens' immunoreactivity scores, after which survival differences between the high (red) and low (blue) FILM protein clusters were analyzed. Humam Kadara et al. Clin Cancer Res 2011;17:1490-1501 ©2011 by American Association for Cancer Research