FILM protein signature predicts poor survival in nontreated stage-IB lung adenocarcinoma. FILM protein signature predicts poor survival in nontreated stage-IB lung adenocarcinoma. Nontreated stage-IA or stage-IB tissue microarray FFPE lung adenocarcinomas were dichotomized into groups of (A) high (black) versus low (grey) risk or (B) divided into 3 groups of high (black), intermediate (dotted), low (grey) risk as predicted by the FILM protein signature. Survival differences between the different groups were statistically assessed by the Kaplan-Meier method and log-rank test. Humam Kadara et al. Clin Cancer Res 2011;17:1490-1501 ©2011 by American Association for Cancer Research