The differential susceptibility to CTL-induced lysis does not involve Melan-A antigen expression. The differential susceptibility to CTL-induced lysis.

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The differential susceptibility to CTL-induced lysis does not involve Melan-A antigen expression. The differential susceptibility to CTL-induced lysis does not involve Melan-A antigen expression. A, the lytic activity of the LT12 CTL clone toward T1 and G1 tumor cells was assessed in a standard 4-h chromium release assay at various E:T ratios as indicated. Percent specific lysis was calculated conventionally. B, cell surface expression of HLA class I molecules and intracellular expression of Melan-A protein by T1 and G1 cells were determined by immunofluorescence analysis by fluorescence-activated cell sorting (FACS) using anti-HLA-A2 (MA2.1) and anti-Melan-A (filled) mAbs. Isotypic IgG1 (negative control) were included (open). Numbers, percentages of positive cells; numbers in brackets, mean fluorescence intensity of specific staining. C, the lytic activity of the LT12 CTL clone toward T1 and G1 tumor cells, pulsed or not pulsed with the natural peptide (EAAGIGILTV) or with the modified peptide (ELAGIGILTV), was assessed in a standard 4-h chromium release assay at various E:T ratios as indicated. Percent specific lysis was calculated conventionally. Representative data of more than three independent experiments are shown. Ahmed Hamaï et al. Cancer Res 2008;68:9854-9864 ©2008 by American Association for Cancer Research