Both the MMP9 and MMP2 systems are activated by anti-Aβ antibodies, IVIg, and mouse IgG. Both the MMP9 and MMP2 systems are activated by anti-Aβ antibodies,

Slides:

Advertisements

Similar presentations

VEGF gene expression in HPMVEC and VEGF protein levels in CM

Advertisements

Figure S2 A B Log2 Fold Change (+/- cAMP) Transcriptome (9hr)

TIMPs MMP MCF-7 RNA MCF-7 + Tenascin 9-16 Long

Proteins enriched in HCs are strongly associated with genetic hearing/balance impairment. Proteins enriched in HCs are strongly associated with genetic.

An anti-CD20–IL-2 immunocytokine is highly efficacious in a SCID mouse model of established human B lymphoma by Stephen D. Gillies, Yan Lan, Steven Williams,

(A) Heat map showing expression changes during in vitro differentiation of nscs to astrocytes. (A) Heat map showing expression changes during in vitro.

by Rong L. He, Jian Zhou, Crystal Z

Podocyte-specific PPAR-γ–deficient mice show increased glomerular TRPC6 expression. Podocyte-specific PPAR-γ–deficient mice show increased glomerular TRPC6.

by Rong Deng, and Joseph P. Balthasar

Volume 15, Issue 2, Pages (February 2007)

p110-free p85 is present in MEFs and certain murine tissues.

FMDV-specific IgG, IgG1, and IgG2 in sera of guinea pigs (n = 6/group) immunized on days 1 and 21 by intramuscular injection of FMDV antigens (type O)

A single DNA vaccination of C57BL/6 mice induced Ab responses of IgG1 and/or IgG2c subclass. A single DNA vaccination of C57BL/6 mice induced Ab responses.

Cocaine exposure downregulates miR-125b expression.

FMD VP1-specific IgG, IgG1, and IgG2 in sera of guinea pigs (n = 6/group) immunized on days 1 and 21 by intramuscular injection of FMDV antigens (type.

Microarray analysis of phospho-Twist1–responsive genes.

Virus-specific serum antibody response of BALB/c mice to DNA prime followed by VRP boost. Virus-specific serum antibody response of BALB/c mice to DNA.

Further Characterization of the Sho-saiko-to-Mediated Anti-Tumor Effect on Melanoma Developed in RET-Transgenic Mice Masashi Kato, Ken-ichi Isobe, Yan.

S100A15, an Antimicrobial Protein of the Skin: Regulation by E

Active avoidance is impaired in aged mice in both multimodal and visual versions of the task. Active avoidance is impaired in aged mice in both multimodal.

Differential expression levels of archaella operon genes and respiratory chain genes in Δsaci_pp2a and Δsaci_ptp. Differential expression levels of archaella.

Effect of route of administration (i.v. versus i.p.).

Quantitative RT-PCR results of relative gene expression normalized to wild-type (WT) expression levels for the LjMYB14 transgene (A) and genes specific.

Marker genes are selected for mouse brain cell types and used to estimate cell type profiles. Marker genes are selected for mouse brain cell types and.

Effects of E2 on levels of phospho-CREB in the DH of OVX females, sham males, and GDX males. Effects of E2 on levels of phospho-CREB in the DH of OVX females,

The first two principal components for the islet gene expression data for the 181 microarray probes that map to the chromosome 6 trans-eQTL hotspot with.

Decreased expression of cell cycle– and apoptosis-related genes in Aml1-excised leukemia cell. Decreased expression of cell cycle– and apoptosis-related.

Neutrophil depletion ameliorates colitis in Cx3cr1cre:Il10rafl/fl BM chimeras. Neutrophil depletion ameliorates colitis in Cx3cr1cre:Il10rafl/fl BM chimeras.

FGF21 signaling in hypothalamus is blocked by FGFR1 neutralizing antibody. FGF21 signaling in hypothalamus is blocked by FGFR1 neutralizing antibody. Twelve-week-old.

IL-6 inhibits insulin-induced formation of p85/IRS-1 complexes.

Expression of candidate neuronal IEGs in the brain of cycloheximide pretreated crickets 30 min after PTX injection. Expression of candidate neuronal IEGs.

PTX-induced reporter protein expression in the brain of the IEG reporter line. PTX-induced reporter protein expression in the brain of the IEG reporter.

Conversion of proBDNF to mature BDNF occurs after the first pairing session of conditioning as shown by Western blot analysis. Conversion of proBDNF to.

Insulin levels are increased in the MBH of Ugcgf/f//CamKCreERT2 mice.

Activation of glial cells.

Western blot analysis of α-Syn-BAC-Tg/GBA-hetero-KO mice at multiple time points. Western blot analysis of α-Syn-BAC-Tg/GBA-hetero-KO mice at multiple.

Increased proIGF-II and decreased IGF-IIR in BTBR compared with B6 mice. Increased proIGF-II and decreased IGF-IIR in BTBR compared with B6 mice. Western.

Secretion of MMP-9 is associated with macrophage-dependent Aβ degradation. Secretion of MMP-9 is associated with macrophage-dependent Aβ degradation. A,

Targeted disruption of the mouse Atp1a2.

ApoE-dependent degradation of Aβ by macrophages.

Csmd2 mRNA is expressed in the mouse forebrain.

Association of MRI findings and serum autoantibodies in diffuse neuropsychiatric systemic lupus erythematosus. Association of MRI findings and serum autoantibodies.

Mek-1/2 activity mediates stress-enhanced Erk-1/2 phosphorylation and fear conditioning. Mek-1/2 activity mediates stress-enhanced Erk-1/2 phosphorylation.

Anti-DNA Abs were not affected by the deletion of GCs in pristane-induced lupus model. Anti-DNA Abs were not affected by the deletion of GCs in pristane-induced.

PTZ-induced c-Fos and Arc proteins in hippocampal dentate gyrus

Ctip2 directly regulates Notch1 expression in differentiated cells.

Expression and localization of Wnt components during sciatic nerve development. Expression and localization of Wnt components during sciatic nerve development.

Chronic sleep loss is associated with microglial phagocytosis.

Oligomeric Aβ42 treatment induces expression of Ras and Cyclin D1 and activation of ERK in primary rat cortical neurons. Oligomeric Aβ42 treatment induces.

Overexpression of IL-27 upregulates expression of multiple IR by T cells in vivo. Overexpression of IL-27 upregulates expression of multiple IR by T cells.

nAChR β2 antibody labeling in WT and β2 KO mouse model.

Expression of Chx10-cre and phenotypes of Chx10-cre induced Smo ablation. Expression of Chx10-cre and phenotypes of Chx10-cre induced Smo ablation. A–G,

A, Cells present in clonal clusters were classified based on morphology (see Materials and Methods) into type 1 progenitor cells (A.1); type 2/3 progenitor.

Upregulation of TRPM2 and production of CXCL2 in cultured macrophages that evoked mechanical allodynia after intraplantar injection. Upregulation of TRPM2.

TOMA does not affect NFTs in posterior hypothalamus or cortex.

TRPM2 deficiency impairs carrageenan-induced inflammatory pain.

Expression of human tau in GFAP/tau Tg mice.

Gene expression changes in the PFC of mice with decreased TrkB expression. Gene expression changes in the PFC of mice with decreased TrkB expression. A-I,

Heat map of genes for which CR significantly altered expression versus AL. Cluster analysis of genes significantly changed by the CR intervention compared.

Effect of local IL-6 immunoneutralization on reversal learning performance. a, c, Representative images of cannula placement and injection sites in the.

Essential role for the overexpression of type I IFN-related genes in the improved chemotherapeutic response of Stat3−/− tumors. Essential role for the.

Pioglitazone induces the clearance of amyloid in APP/PS1 mice.

Depletion of Gr-1+ neutrophils by systemic anti-Gr-1 treatment prevents exacerbated neurodegeneration in RAG1-KO mice. Depletion of Gr-1+ neutrophils by.

Gene expression in the PFC of mice with an inducible neuron-specific bdnf knock-out in embryogenesis. Gene expression in the PFC of mice with an inducible.

PDL192 and inhibit the growth of xenograft tumors.

PARP1 suppresses the transcription of PD-L1 in cancer cells.

Administration of anti-glial cell line-derived neurotrophic factor (anti-GDNF) antibodies reduces liver fibrosis development in mice. Administration of.

In the absence of TLR5 and inflammasome recognition, FliC’s D2/D3 domains are essential for secondary IgG1 and IgG2c anti-flagellin responses. In the absence.

Therapeutic administration of an anti-podoplanin antibody (α-PDPN) is beneficial during a mouse model of acute respiratory distress syndrome. Therapeutic.

Binding of TCP4-Like Proteins to the SAUR Promoters Is Enhanced by Light Signal or the Lack of PIFs. (A) and (B) Light increases the binding of TCP4 to.

Presentation transcript:

Both the MMP9 and MMP2 systems are activated by anti-Aβ antibodies, IVIg, and mouse IgG. Both the MMP9 and MMP2 systems are activated by anti-Aβ antibodies, IVIg, and mouse IgG. A, C, Show relative gene expression of components of the MMP9 system (A) and the MMP2 system (C). Gene expression is shown as fold change compared with mice receiving saline injection at the given time point. B, D, Show protein expression of MMP9 and TIMP1 (B), and MMP2 and TIMP1 (D) measured by ELISA. *p < 0.05; **p < 0.01 for the data point shown compared with all other datasets at that time point. Where multiple groups are together, the statistical significance is compared with saline. Tiffany L. Sudduth et al. J. Neurosci. 2013;33:9684-9692 ©2013 by Society for Neuroscience