Acute applications display only slight pharmacological differences among menthol stereoisomers. Acute applications display only slight pharmacological.

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Acute applications display only slight pharmacological differences among menthol stereoisomers. Acute applications display only slight pharmacological differences among menthol stereoisomers. A, Concentration–response curves of ACh on oocytes injected with α4 and β2 nAChR subunits. Injections were biased to assemble high-sensitivity (α4)2(β2)3 nAChRs (1:10) or low-sensitivity (α4)3(β2)2) nAChRs (10:1). B1, B2, Concentration–response curve of menthol stereoisomers with high sensitivity (α4)2(β2)3 nAChRs (B1) or low sensitivity (α4)3(β2)2 nAChRs (B2). C1, C2, Concentration–response curve of ACh in the absence or presence of (−)-menthol or (+)-menthol (50 µm) with high sensitivity (α4)2(β2)3 nAChRs (C1) or low sensitivity (α4)3(β2)2 nAChRs (C2). Refer to Tables 1–3 for values for Hill coefficient, EC50, and IC50. Brandon J. Henderson et al. eNeuro 2018;5:ENEURO.0465-18.2018 ©2018 by Society for Neuroscience