PKM2 activation was suppressed by overexpression of MnSOD during early skin carcinogenesis. PKM2 activation was suppressed by overexpression of MnSOD during.

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PKM2 activation was suppressed by overexpression of MnSOD during early skin carcinogenesis. PKM2 activation was suppressed by overexpression of MnSOD during early skin carcinogenesis. Mouse skin epidermal cells were collected and whole-cell lysate was used for Western blot analysis (A) and PKM2 activity assay (B). nTg, skin epidermal samples from nontransgenic (wild-type) mice; TgH, skin epidermal samples from MnSOD transgenic mice; Ctrl, control (DMSO) treatment group. *, P < 0.05 compared with the control group. Jennifer A. Wittwer et al. Cancer Prev Res 2011;4:1476-1484 ©2011 by American Association for Cancer Research