Examples of “classical” small airway disease in severe asthma from video-assisted thoracoscopic surgery procured tissue showing small airways with epithelial.

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Examples of “classical” small airway disease in severe asthma from video-assisted thoracoscopic surgery procured tissue showing small airways with epithelial hyperplasia and mucous plugs (black squares), prominent smooth muscle hyperplasia/hypertrophy (aste... Examples of “classical” small airway disease in severe asthma from video-assisted thoracoscopic surgery procured tissue showing small airways with epithelial hyperplasia and mucous plugs (black squares), prominent smooth muscle hyperplasia/hypertrophy (asterisks), thickened basement membrane (arrowheads) and adventitial eosinophilic/lymphocytic inflammation extending into areas of alveolar attachments (arrows). a) 100× magnification, b) 400× magnification. Daniel Doberer et al. Eur Respir Rev 2015;24:525-539 ©2015 by European Respiratory Society