Of Mice and Men: Not ExAKTly the Same?

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Of Mice and Men: Not ExAKTly the Same? Min Wan, Morris J. Birnbaum Cell Metabolism Volume 14, Issue 6, Pages 722-723 (December 2011) DOI: 10.1016/j.cmet.2011.11.009 Copyright © 2011 Elsevier Inc. Terms and Conditions

Figure 1 Summary of Insulin's Effects on Glucose and Lipids In mice, there are abundant data supporting the idea that insulin produces many effects on metabolism by activating Akt2. These include increased glucose uptake into muscle and fat and decreased production from liver. The discovery of an activating mutation in Akt2 that leads to the same phenotype in humans as hyperinsulinemia lends strong support to the idea that this pathway is conserved between man and mice. Cell Metabolism 2011 14, 722-723DOI: (10.1016/j.cmet.2011.11.009) Copyright © 2011 Elsevier Inc. Terms and Conditions