Long-term outcomes in pediatric-onset esophageal eosinophilia Charles W. DeBrosse, MD, James P. Franciosi, MD, MS, MSCE, Eileen C. King, PhD, Bridget K. Buckmeier Butz, MHSA, Allison B. Greenberg, BA, Margaret H. Collins, MD, J. Pablo Abonia, MD, Amal Assa’ad, MD, Philip E. Putnam, MD, Marc E. Rothenberg, MD, PhD  Journal of Allergy and Clinical Immunology  Volume 128, Issue 1, Pages 132-138 (July 2011) DOI: 10.1016/j.jaci.2011.05.006 Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Identification and recruitment of study participants. After histologic review of esophageal biopsy specimens obtained between 1982 and 1999, patients were categorized as having rEoE (≥15 eosinophils/hpf) or CE (<15 eosinophils/hpf). A healthy control group was also identified. Patients were then invited to complete validated outcome metrics. Journal of Allergy and Clinical Immunology 2011 128, 132-138DOI: (10.1016/j.jaci.2011.05.006) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Clinical features of the control, CE, rEoE, and DxEoE cohorts. Patients completed metrics for dysphagia (MDQ), food allergy, and quality of life (SF-12). The percentage of patients in the control, CE, and rEoE cohorts reporting dysphagia and food allergy, as well as median quality of life, were calculated (A). Data were reanalyzed with the subgroup of DxEoE removed from the rEoE and CE cohorts and classified independently (B). Journal of Allergy and Clinical Immunology 2011 128, 132-138DOI: (10.1016/j.jaci.2011.05.006) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Reported rates of dysphagia and peak esophageal eosinophil counts. Logistic regression analysis and receiver operating characteristic curves were generated to identify the relationship between dysphagia and peak esophageal eosinophil counts. The blue line represents the relationship between eosinophil counts and the probability of having dysphagia. Journal of Allergy and Clinical Immunology 2011 128, 132-138DOI: (10.1016/j.jaci.2011.05.006) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions