Comprehensive chromosome screening alters traditional morphology-based embryo selection: a prospective study of 100 consecutive cycles of planned fresh.

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Presentation transcript:

Comprehensive chromosome screening alters traditional morphology-based embryo selection: a prospective study of 100 consecutive cycles of planned fresh euploid blastocyst transfer Eric J. Forman, M.D., Kathleen M. Upham, B.S., Michael Cheng, B.S., Tian Zhao, B.S., Kathleen H. Hong, M.D., Nathan R. Treff, Ph.D., Richard T. Scott, M.D. Fertility and Sterility Volume 100, Issue 3, Pages 718-724 (September 2013) DOI: 10.1016/j.fertnstert.2013.04.043 Copyright © 2013 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Real-time, quantitative polymerase chain reaction (PCR)-based comprehensive chromosome screening results after day 5 trophectoderm biopsy of four blastocysts from a 31-year-old patient with a history of recurrent pregnancy loss. Had a day 5 elective single ET been performed, the top embryo would have been selected based on morphological criteria. After comprehensive chromosome screening results were obtained, that embryo was found to be aneuploid (47,XY,+21). On the morning of day 6, the embryo with the karyotype prediction of 46,XY was transferred, although its morphology grade was 4BB, compared with 6AA for the 47,XY,+21 embryo. The patient delivered a healthy boy at 39 weeks, 4 days gestation. Fertility and Sterility 2013 100, 718-724DOI: (10.1016/j.fertnstert.2013.04.043) Copyright © 2013 American Society for Reproductive Medicine Terms and Conditions