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Volume 79, Issue 10, Pages 1113-1118 (May 2011) Tubular markers do not predict the decline in glomerular filtration rate in type 1 diabetic patients with overt nephropathy Stine E. Nielsen, Steen Andersen, Dietmar Zdunek, Georg Hess, Hans-Henrik Parving, Peter Rossing Kidney International Volume 79, Issue 10, Pages 1113-1118 (May 2011) DOI: 10.1038/ki.2010.554 Copyright © 2011 International Society of Nephrology Terms and Conditions

Figure 1 Design of the study. Kidney International 2011 79, 1113-1118DOI: (10.1038/ki.2010.554) Copyright © 2011 International Society of Nephrology Terms and Conditions

Figure 2 Scatter plot of baseline urinary neutrophil gelatinase-associated lipocalin (u-NGAL) versus decline in glomerular filtration rate (GFR) during the study period (R=0.32, P=0.02). Kidney International 2011 79, 1113-1118DOI: (10.1038/ki.2010.554) Copyright © 2011 International Society of Nephrology Terms and Conditions

Figure 3 Scatter plot of baseline urinary kidney injury molecule-1 (u-KIM1) versus decline in glomerular filtration rate (GFR) during the study period (R=0.24, P=0.1). Kidney International 2011 79, 1113-1118DOI: (10.1038/ki.2010.554) Copyright © 2011 International Society of Nephrology Terms and Conditions

Figure 4 Effect of losartan on tubular markers. (a) Reductions in log-transformed urinary kidney injury molecule-1 (u-KIM1) during losartan treatment. KIM1 is significantly decreased from baseline (no difference from 1 to 3 years). Error bars indicate 95% confidence interval. (b) Reductions in log-transformed u-KIM1 during losartan treatment, expressed in percentages. Kidney International 2011 79, 1113-1118DOI: (10.1038/ki.2010.554) Copyright © 2011 International Society of Nephrology Terms and Conditions