Linear correlationa between TMB cutoff for ORb for CR/PR rates and HRc for PFS, and OS depending on TMB for patients treated with anti-PD-1/PD-L1 monotherapy.

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Linear correlationa between TMB cutoff for ORb for CR/PR rates and HRc for PFS, and OS depending on TMB for patients treated with anti-PD-1/PD-L1 monotherapy (N = 102). Linear correlationa between TMB cutoff for ORb for CR/PR rates and HRc for PFS, and OS depending on TMB for patients treated with anti-PD-1/PD-L1 monotherapy (N = 102). A, OR for CR/PR rate depending on TMB cutoff (R2 = 0.1985, P = 0.0106, Y = 0.07617X + 7.494). B, HR for PFS depending on TMB cutoff (R2 = 0.1246, P = 0.0487, Y = −0.001184X + 0.3886). C, HR for OS depending on TMB cutoff (R2 = 0.1985, P = 0.0476, Y = −0.001275X + 0.5462). a, Linear regression performed using the least squares method. b, OR >1.0 implies higher chance of response. The OR was calculated by comparing RR above and below the cut-off for each value. c, HR < 1.0 implies less chance of progression or death. The HR was evaluated by comparing OS above and below the cut-off for each value. CR, complete response; PD, progressive disease; PR, partial response; SD, stable disease. Aaron M. Goodman et al. Mol Cancer Ther 2017;16:2598-2608 ©2017 by American Association for Cancer Research