Binding of mRNA to the 30S ribosomal subunit.

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Ribosome Structure 1. Outline the structure of a ribosome based on the diagram: ● A site.

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Presentation transcript:

Binding of mRNA to the 30S ribosomal subunit. Binding of mRNA to the 30S ribosomal subunit. (A) Binding of a canonical mRNA to the 30S ribosomal subunit. Two alternative pathways are shown where either the mRNA or the fMet-tRNAfMet binds first, followed by the other component. The mRNA is bound via the SD-ASD interaction as well as the codon-anticodon interaction. (B) Binding of a leaderless mRNA to the 30S ribosomal subunit. The mRNA is bound to the ribosome mainly via the codon-anticodon interaction. IF2 stimulates the binding of leaderless mRNAs, presumably by recruitment of fMet-tRNAfMet to the subunit. Brian Søgaard Laursen et al. Microbiol. Mol. Biol. Rev. 2005; doi:10.1128/MMBR.69.1.101-123.2005