Fyn cooperates with Src to increase the tumorigenic potential of PTB-independent ShcA signaling complexes. Fyn cooperates with Src to increase the tumorigenic.

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Fyn cooperates with Src to increase the tumorigenic potential of PTB-independent ShcA signaling complexes. Fyn cooperates with Src to increase the tumorigenic potential of PTB-independent ShcA signaling complexes. Immunoblot blot analysis of whole-cell lysates from ShcAWT (A) and PTBMUT (B) cell lines upon deletion of Src, Fyn, or Lyn using Crispr/Cas9 genomic editing. Number (C and E) and average area (D and F) of foci formed in a soft agar assay from specified cell lines. The data are representative of three independent experiments (means ± SEM). *, P < 0.05; **, P < 0.01. The fold change in number (G and I) and average area (H and J) of foci formed in soft agar of indicated cell lines relative to DMSO controls in the absence or presence of PP2 (2 μmol/L) or Torin1 (50 nmol/L). The data is representative of three independent experiments (means ± SEM). DMSO versus PP2 or Torin1 treatment: *, P < 0.05; **, P < 0.01; ****, P < 0.0001. VC versus Src-CR: δ, P < 0.05; δδ, P < 0.01; δδδ, P < 0.001; δδδδ, P < 0.0001. Jacqueline R. Ha et al. Mol Cancer Res 2018;16:894-908 ©2018 by American Association for Cancer Research