Molecular signatures are independent of tumor stage and grade.

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Presentation transcript:

Molecular signatures are independent of tumor stage and grade. Molecular signatures are independent of tumor stage and grade. Heat maps showing mean expression levels of gene signatures/individual genes in each of the 5 molecular subtypes stratified by tumor stage; Ta, T1, and muscle-invasive tumors (MI; A), and by tumor grade (B). Expression of target genes for tipifarnib (FNTA) and valrubicin (TOP2A) is shown. Red, high expression; green, low expression; gray fields, insufficient data. Gottfrid Sjödahl et al. Clin Cancer Res 2012;18:3377-3386 ©2012 by American Association for Cancer Research