Efficiencies of conversion of BSE GR to urinary SF and DTC in two populations. Efficiencies of conversion of BSE GR to urinary SF and DTC in two populations.

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Efficiencies of conversion of BSE GR to urinary SF and DTC in two populations. Efficiencies of conversion of BSE GR to urinary SF and DTC in two populations. A, Baltimore: 131 conversion determinations on 45 volunteers who received a single oral dose of BSE containing 200 μmol of GR. The total 24-hour excretion of SF and DTC, measured by cyclocondensation reaction, is expressed as a percentage of dose. The first observation made on each subject is identified separately (Δ) from subsequent determinations (•). The lowest conversion was 2.2 μmol (1.1% of dose) and the highest was 81.3 μmol (40.7%). B, Qidong, China. The subjects (n = 99) received BSE containing 400 μmol of GR each evening for 14 days. All overnight urine (approximately 12 hours) was analyzed by cyclocondensation reaction. The 396 values shown represent the values for each subject, determined on 4 days. Excretion values ranged from 4.1 to 180 μmol DTC (1.02%–45% of administered dose). Normal distributions are superimposed on distribution histograms for each dataset, in insets to Fig. 1A and B. Because collection periods are not the same in the two studies, the results are not directly quantitatively comparable, but the patterns are remarkably similar. Thus the mean excretion was 10.4% to 11.8% of dose, and only about 20% of the observations in both studies exceeded the midpoint (approximately 20%) of conversion of the administered dose. Jed W. Fahey et al. Cancer Prev Res 2012;5:603-611 ©2012 by American Association for Cancer Research