Fiona H. Marshall Trends in Biochemical Sciences

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Presentation transcript:

Visualizing GPCR ‘Megaplexes’ Which Enable Sustained Intracellular Signaling Fiona H. Marshall Trends in Biochemical Sciences Volume 41, Issue 12, Pages 985-986 (December 2016) DOI: 10.1016/j.tibs.2016.10.006 Copyright © 2016 Elsevier Ltd Terms and Conditions

Figure 1 Binding of β-Arrestin to the GPCR Results in Receptor Internalization to Endosomes. The β-arrestin-bound GPCR is able to couple to heterotrimeric G proteins within the endosome, forming a ‘megaplex’. Activation of the G protein within the megaplex results in dissociation of the Gβs subunit which can activate endosomal adenylate cyclase leading to the sustained production of cAMP. Trends in Biochemical Sciences 2016 41, 985-986DOI: (10.1016/j.tibs.2016.10.006) Copyright © 2016 Elsevier Ltd Terms and Conditions