Systemic responses after bronchial aspirin challenge in sensitive patients with asthma Joanna S. Makowska, MD, PhD, Janina Grzegorczyk, PhD, Barbara Bienkiewicz,

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Presentation transcript:

Systemic responses after bronchial aspirin challenge in sensitive patients with asthma Joanna S. Makowska, MD, PhD, Janina Grzegorczyk, PhD, Barbara Bienkiewicz, MD, PhD, Maria Wozniak, MD, PhD, Marek L. Kowalski, MD, PhD Journal of Allergy and Clinical Immunology Volume 121, Issue 2, Pages 348-354 (February 2008) DOI: 10.1016/j.jaci.2007.09.039 Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Blood for flow cytometry and cytokine analysis was collected at the following time points: P0, before placebo inhalation; P1, 1 hour after completion of placebo administration; P20 = A0, 20 hours after placebo administration (the baseline for aspirin challenge); A1, 1 hour after aspirin-induced reaction (in patients with positive reaction) or 1 hour after completion of aspirin administration (in patients with negative challenge); A20, 20 hours after reaction caused by aspirin (in patients with positive reaction) or 1 hour after completion of aspirin administration (in patients with negative challenge). Journal of Allergy and Clinical Immunology 2008 121, 348-354DOI: (10.1016/j.jaci.2007.09.039) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 The percentage of leukocyte progenitor cells (A) and eosinophil progenitor cells (B) after bronchial challenge with lysine-aspirin in patients with negative and positive reaction (∗P < .05, ∗∗P < .005 compared with A0). Journal of Allergy and Clinical Immunology 2008 121, 348-354DOI: (10.1016/j.jaci.2007.09.039) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 The percentage of leukocyte progenitor cells (A) and eosinophil progenitor cells (B) after bronchial challenge with lysine-aspirin in patients with isolated bronchial reactions, systemic reactions, and negative response (∗P < .05; ∗∗P < .005 compared with A0). Journal of Allergy and Clinical Immunology 2008 121, 348-354DOI: (10.1016/j.jaci.2007.09.039) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 4 Serum concentrations of eotaxin 2 after bronchial challenge with lysine-aspirin in patients with positive and negative response (∗P < .05 compared with A0). Journal of Allergy and Clinical Immunology 2008 121, 348-354DOI: (10.1016/j.jaci.2007.09.039) Copyright © 2008 American Academy of Allergy, Asthma & Immunology Terms and Conditions