Fig. 3 LRRK2 activation in nigrostriatal dopamine neurons in two rat models of PD. LRRK2 activation in nigrostriatal dopamine neurons in two rat models.

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Fig. 3 LRRK2 activation in nigrostriatal dopamine neurons in two rat models of PD. LRRK2 activation in nigrostriatal dopamine neurons in two rat models of PD. (A) Shown are pSer1292 and 14-3-3–LRRK2 proximity ligation signals in the substantia nigra of the brains of rats treated with vehicle (control, top row) or the pesticide rotenone (bottom row). In the rotenone-treated rats, there was increased pSer1292 proximity ligation signal and loss of 14-3-3–LRRK2 proximity ligation signal, indicating LRRK2 activation. TH, tyrosine hydroxylase, a marker of dopamine neurons (blue). (B) Quantification of pSer1292 proximity ligation signal in nigrostriatal dopamine neurons from control vehicle- and rotenone-treated rats. Symbols represent individual animals. Statistical comparison by unpaired two-tailed t test. (C) Quantification of 14-3-3–LRRK2 proximity ligation signal in nigrostriatal dopamine neurons from control vehicle- and rotenone-treated rats. Symbols represent individual animals. Statistical comparison by unpaired two-tailed t test. (D) Shown are pSer1292 proximity ligation signal and 14-3-3–LRRK2 proximity ligation signal in the substantia nigra of the brains of rats that received a unilateral injection of AAV2-hSNCA into one brain hemisphere. In the hemisphere overexpressing α-synuclein (bottom row), there was increased pSer1292 proximity ligation signal and loss of 14-3-3–LRRK2 proximity ligation signal, indicating LRRK2 activation in nigrostriatal neurons compared to the hemisphere that was not injected (top row). (E) Quantification of pSer1292 proximity ligation signal in nigrostriatal dopamine neurons from the control and AAV-hSNCA–injected rat brain hemispheres. Symbols represent mean values from each hemisphere. Statistical comparison by paired two-tailed t test. (F) Quantification of 14-3-3–LRRK2 proximity ligation signal in nigrostriatal dopamine neurons from the control and AAV-hSNCA–injected rat brain hemispheres. Symbols represent mean values from each hemisphere. Statistical comparison by paired two-tailed t test. Roberto Di Maio et al., Sci Transl Med 2018;10:eaar5429 Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works