Fig. 4 Overexpression of SBP2 improved insulin sensitivity and suppressed adipogenesis in obese mice. Overexpression of SBP2 improved insulin sensitivity.

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Fig. 4 Overexpression of SBP2 improved insulin sensitivity and suppressed adipogenesis in obese mice. Overexpression of SBP2 improved insulin sensitivity and suppressed adipogenesis in obese mice. (A) SBP2 restoration induced (B) expression of M2-like genes instead of M1-like ones in sorted ATMs of db/db mice. SBP2 overexpression (C) did not change the body weight but (D) reduced adipose tissue weight, (E) improved FBG levels, (F) glucose intolerance and (G) insulin sensitivity, (H) serum HbA1c levels, (I) sensitized adipose insulin-responsive Akt pathway, and (J) reduced macrophage infiltration in adipose tissue. (K) Reexpression of SBP2 reduced M1-like macrophages but increased M2-like populations. (L) Sorted SBP2-overexpressing ATMs exhibited reduced inflammasome activation. SBP2 overexpression induced (M) smaller adipocyte diameters and (N) reduced expression of lipogenesis-associated genes. *P < 0.05, **P < 0.01, ***P < 0.001. Ning Wang et al. Sci Adv 2019;5:eaav0198 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).