FKBP1b counters the age-related decrease in hippocampal MAP2 protein expression. FKBP1b counters the age-related decrease in hippocampal MAP2 protein expression.

Slides:

Advertisements

Similar presentations

FMRP suppresses dendritic Arc protein levels.

Advertisements

Fig. 2. The expression of pKr-2 in the substantia nigra (SN) of patients with Parkinson's disease (PD). (A, B) Western blot analysis for pKr-1-2 and pKr-2,

Motor Protein KIF1A Is Essential for Hippocampal Synaptogenesis and Learning Enhancement in an Enriched Environment Makoto Kondo, Yosuke Takei, Nobutaka.

AG-221 induces the differentiation of IDH2R140Q blasts along myeloid lineages in primary human AML xenograft models. AG-221 induces the differentiation.

Effect of α2δ-1 ablation on distribution of CaV2

Fig. 6. C3 deficiency resulted in partial sparing of neuron loss in hippocampal CA3 in 16-month-old APP/PS1 mice. C3 deficiency resulted in partial sparing.

Dendritic spine density at P30 is elevated on isolated PirB−/− neurons in layer 2/3 after sparse excision of PirB at E15.5. Dendritic spine density at.

Density of dendritic spines on L2/3 pyramidal neurons is greater in visual cortex of germline PirB−/− mice than in PirB+/+ mice at P30. Density of dendritic.

Characterization of DPR proteins in primary rat neurons and HEK293 cells. Characterization of DPR proteins in primary rat neurons and HEK293 cells. GFP,

Lgc-35(L324S) homozygous knock-in animals exhibit less severe phenotypes than extrachromosomal or integrated transgene overexpression. lgc-35(L324S) homozygous.

CCL21 localizes to T cell zone FRCs in young and aged spleens.

Surface renderings of the brain activation showing significant activation in the general mixed design ANOVA for the interaction between all three factors,

Nicotine inhibits hippocampal and striatal acetylcholinesterase activities, and demonstrates dual action on adult neuronal proliferation and maturation

Activation of PBN and CeA by illuminating the hindpaw after PNI

Long-lasting lemniscal fiber remodeling related to ectopic receptive fields of V2 VPM neurons and mechanical hypersensitivities on ectopic receptive fields.

IONC increased non-PrV2-origin lemniscal fiber terminals in V2 VPM related to newly recruited lemniscal fibers onto VPM neurons. IONC increased non-PrV2-origin.

GlyR activation modulates its diffusion properties around active synapses. GlyR activation modulates its diffusion properties around active synapses. A,

DFP-induced astrogliosis is reduced by urethane.

Ab-dependent synaptic loss and neuritic dystrophies in adult APP/PSEN1 and APP/PSEN1/APOEnull mice. Ab-dependent synaptic loss and neuritic dystrophies.

Decreased P-IR and total FOXO1 levels in an HFS diet.

Loss of LAR phosphatase activity is associated with decreased adhesion complex formation. Loss of LAR phosphatase activity is associated with decreased.

Fig. 1 KCC2 down-regulation is prevented in sortilin-deficient mice.

CRISPRa sgRNA multiplexing for synergistic or coordinated control of gene expression. CRISPRa sgRNA multiplexing for synergistic or coordinated control.

The complexity as well as the total dendritic length of ApoE-deficient adult-born granule cells are significantly reduced. The complexity as well as the.

The complexity and the total dendritic length of ApoE4 adult-born granule cells are significantly reduced. The complexity and the total dendritic length.

APT1 palmitoylation and localization.

Increased phosphorylation of Akt, Girdin S1416, and NR2B of NMDA receptor in the hippocampus of mouse after fear conditioning. Increased phosphorylation.

Fig. 4. Reduction of apoptosis and autophagic stress by treatment with silibinin in the KA-treated hippocampus. (A, B) Double-immunofluorescence staining.

Loss of ATF3 function modestly reduces axonal regeneration following sciatic nerve crush. Loss of ATF3 function modestly reduces axonal regeneration following.

Fig. 3. Neuroprotective effects of silibinin against KA-induced excitotoxicity. (A) Silibinin was intraperitoneally injected for 8 days, starting 1 day.

Fig. 5. Anti-inflammatory effects of silibinin on KA treatment in the hippocampus. (A) Representative coronal sections of the hippocampal CA1 region following.

Microglia activation in distinct sites of the spinal cord from mice with bronchial asthma or atopic dermatitis on the back skin at the thoracic spinal.

Synaptic density is significantly impaired in male FBN-ARO-KO mice.

Β-Actin overexpression in hippocampal neurons with ZBP1 knockdown is sufficient for partial phenotype rescue. β-Actin overexpression in hippocampal neurons.

miR-9 regulation of Pax6 expression.

PTZ-induced c-Fos and Arc proteins in hippocampal dentate gyrus

Interference of Kv4 in dorsal neurons (DN1s) does not significantly regulate sleep onset. Interference of Kv4 in dorsal neurons (DN1s) does not significantly.

Diaphanous regulates the presynaptic actin cytoskeleton.

Knockdown of ZBP1 in hippocampal neurons decreases dendritic branching

ADCY5 is expressed in isolated human islets and affected by T2D risk alleles. ADCY5 is expressed in isolated human islets and affected by T2D risk alleles.

PTZ-induced neuronal activity visualized by IEGs

Effect of PPARγ agonist on Aβ phagocytosis in primary microglia.

Effects of an AMPA receptor antagonist on numbers of pCofilin-positive spines. Effects of an AMPA receptor antagonist on numbers of pCofilin-positive spines.

Transgenic expression of mCREB or CREB produces opposite effects in the learned helplessness model of depression. Transgenic expression of mCREB or CREB.

The developmental spine morphology changes predict decreased biochemical compartmentalization with age, while loss of FMRP subtly influences this in an.

Astroglial activation in distinct sites of the spinal cord from mice with bronchial asthma or atopic dermatitis on the back skin at the thoracic spinal.

TBS- and HFS activate different signaling pathways.

Developmental changes in Scn1a expression and susceptibility to hyperthermia-induced seizures. Developmental changes in Scn1a expression and susceptibility.

CRISPRa induction of Bdnf mRNA increases spike and burst frequency in hippocampal neurons cultured on microelectrode arrays (MEAs). CRISPRa induction of.

Knock-out of NSG2 decreases mEPSC frequency.

NPC-derived oligodendrocytes are maintained long term after cuprizone challenge. NPC-derived oligodendrocytes are maintained long term after cuprizone.

The repertoire of NPC-derived cells within the CC during cuprizone-induced demyelination. The repertoire of NPC-derived cells within the CC during cuprizone-induced.

Fig. 6. C3 deficiency resulted in partial sparing of neuron loss in hippocampal CA3 in 16-month-old APP/PS1 mice. C3 deficiency resulted in partial sparing.

Gld2 and Ngd regulate glycine-induced GluN2A synthesis and surface expression in dendrites. Gld2 and Ngd regulate glycine-induced GluN2A synthesis and.

A, Hippocampal protein levels of IL-6 in LD and DD mice treated with PDTC, ASA, or saline controls. A, Hippocampal protein levels of IL-6 in LD and DD.

Amppos tumors are a distinct tumor subpopulation.

Coexpression of Crf and Tac2 (A-P -1.5).

Manipulation of Sox11 shifts the abundance of differentiated neurons and apical progenitors. Manipulation of Sox11 shifts the abundance of differentiated.

At P23, dendritic spine density on L2/3 pyramidal cells in PirB−/− visual cortex is similar to that of PirB+/+. At P23, dendritic spine density on L2/3.

Quantification of TUNEL staining and OS length among the rab11a constructs. Quantification of TUNEL staining and OS length among the rab11a constructs.

SIRT1 deletion exacerbates premature lethality and synapse loss in tauP301S mice. SIRT1 deletion exacerbates premature lethality and synapse loss in tauP301S.

Gene expression in the PFC of mice with an inducible neuron-specific bdnf knock-out in embryogenesis. Gene expression in the PFC of mice with an inducible.

PC loss in Nhe6-null mouse cerebellum, female and male.

The effect of a DIO regimen ± EPA+DHA supplementation on tumor growth.

Pomalidomide decreases fibrosis in the lesion areas of the pancreas of KC mice. Pomalidomide decreases fibrosis in the lesion areas of the pancreas of.

Fig. 5 C9orf72 knockdown disrupts autophagy induction.

Effects of rapamycin, cycloheximide, and an MAP kinase inhibitor (U0126) on BDNF-mediated increase in Arc and CaMKII in acute hippocampal slices. Effects.

Coexpression of Crf, Tac2, and Prkcd; and Sst, Tac2, and Prkcd (A-P -0

Coculture with U937 cells enhances DNMT1 expression in gastric cancer cells. Coculture with U937 cells enhances DNMT1 expression in gastric cancer cells.

A, B, 5-HT1A immunoreactivity in hippocampal dendrites (CA3) of saline-treated (A) and fluoxetine-treated (B) rats. A, B, 5-HT1A immunoreactivity in hippocampal.

Presentation transcript:

FKBP1b counters the age-related decrease in hippocampal MAP2 protein expression. FKBP1b counters the age-related decrease in hippocampal MAP2 protein expression. Top, Semiquantitative measures of MAP2 IHC staining densities plotted as a function of treatment. Statistical analysis revealed a significant effect (p = 0.0015; one-way ANOVA) with a significant decrease from YC to AC that was countered by ST FKPB1b (**p ≤ 0.01, ***p ≤ 0.001, †n.s. trend p = 0.06; post hoc Fisher's pLSD vs AC). Bottom, Immunostaining for hippocampal MAP2 expression. Representative photomicrographs are shown from YC (rectangle defines region of quantitation; A), AC (B), aged ST FKBP1b (C), and aged LT FKBP1b (D). Scale bar, 500 μm. John C. Gant et al. J. Neurosci. 2018;38:1030-1041 ©2018 by Society for Neuroscience