Role of CETP in plasma cholesterol transport.

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Presentation transcript:

Role of CETP in plasma cholesterol transport. Role of CETP in plasma cholesterol transport. Cells in extrahepatic tissues eliminate any cholesterol that is surplus to their needs by transferring it as free (unesterified) cholesterol to HDLs in the extracellular space. The free (unesterified) cholesterol in HDLs is then either delivered to the liver in a process dependent on hepatic scavenger receptor B1or is converted into cholesteryl esters by LCAT. The cholesteryl esters formed in HDLs are subsequently transported to the liver by either of two pathways: 1) a direct pathway that is scavenger receptor B1 dependent and 2) an indirect pathway in which HDL cholesteryl ester are first transferred to the VLDL/LDL fraction by CETP and then taken up by the liver after binding of LDLs to LDL receptors. CE, cholesteryl ester; FC, free (unesterified) cholesterol; LDL-R, low-density lipoprotein receptor; SR-B1, scavenger receptor B1. Philip J. Barter, and Kerry-Anne Rye Pharmacol Rev 2016;68:458-475 Copyright © 2016 by The American Society for Pharmacology and Experimental Therapeutics