Overview of folate and methionine metabolism pathways. Overview of folate and methionine metabolism pathways. TS, thymidylate synthase; DHF, dihydrofolate; THF, tetrahydrofolate; 5,10-CH2-THF, 5,10-methylenetetrahydrofolate; 5-CH3-THF, 5-methyltetrahydrofolate; 10-CHO-THF, 10-formyltetrahydrofolate; CoI, cob(I)alamin; CoII, cob(II)alamin; CoIII, cob(III)alamin; SAM, S-adenosylmethionine; SAH, S-adenosylhomocysteine. Donato Gemmati et al. Cancer Epidemiol Biomarkers Prev 2004;13:787-794 ©2004 by American Association for Cancer Research