Increase in proliferation and activation of immune cells in peripheral blood after NKTR-214 treatment. Increase in proliferation and activation of immune.

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A All patients Arm A Arm B Deaths/patients 21/30 7/10 14/20

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Presentation transcript:

Increase in proliferation and activation of immune cells in peripheral blood after NKTR-214 treatment. Increase in proliferation and activation of immune cells in peripheral blood after NKTR-214 treatment. Peripheral blood mononuclear cell samples were obtained from 22 patients before treatment on day 1 and after treatment on day 8. A, Percentage of Ki-67+ cells within CD4+ T cells (top), CD8+ T cells (center), and CD3−CD56+ NK cells (bottom) was analyzed by flow cytometry. Representative dot plots are shown on the left. B, ICOS (top) and PD-1 (bottom) expression by proliferating (Ki-67+) and nonproliferating (Ki-67−) cells at day 8 after treatment with NKTR-214. Paired t test: *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001. Salah-Eddine Bentebibel et al. Cancer Discov 2019;9:711-721 ©2019 by American Association for Cancer Research