IGF-IR in human head and neck cancer.

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IGF-IR in human head and neck cancer. IGF-IR in human head and neck cancer. A, Western blot analysis of IGF-IR and vinculin (as a loading control) in SCCHN cell lines. Western blot analysis (B) and scanning densitometry ratios (C) of IGF-IR and vinculin expression in paired normal and tumor tissue from tongue cancer patients. D, control nonspecific (NS) or IGF-IR–specific siRNA was transiently transfected into 183A cells and protein expression was assessed 3 d later by Western blot. E, 183A or TU159 cells were transiently transfected with control (nonspecific) or IGF-IR–specific siRNA and total cell counts were assessed 3 d later. *, P < 0.05, different from normal tissue (C) and the cell line–specific control group (E). Christopher J. Barnes et al. Clin Cancer Res 2007;13:4291-4299 ©2007 by American Association for Cancer Research