Fig. 4 Dox-CBD-SA treatment shows reduced toxicity.

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Fig. 4 Dox-CBD-SA treatment shows reduced toxicity. Dox-CBD-SA treatment shows reduced toxicity. Aldoxorubicin or Dox-CBD-SA (20 mg/kg on a Dox basis) was administered to tumor-free FVB mice via tail vein injection on day 0. (A to D) Plasma cytokine concentrations on day 3. (E) Red blood cell (RBC) counts on day 6. (F) White blood cell (WBC) counts on day 3. (G) Spleen weights on day 16. Data represent mean ± SEM. Two experimental replicates. Statistical analyses were done using ANOVA with Tukey’s test. *P < 0.05; **P < 0.01. Koichi Sasaki et al. Sci Adv 2019;5:eaaw6081 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).