Is Cyclin D1-CDK4 kinase a bona fide cancer target?

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Is Cyclin D1-CDK4 kinase a bona fide cancer target? Marcos Malumbres, Mariano Barbacid Cancer Cell Volume 9, Issue 1, Pages 2-4 (January 2006) DOI: 10.1016/j.ccr.2005.12.026 Copyright © 2006 Elsevier Inc. Terms and Conditions

Figure 1 Therapeutic opportunities to block ErbB-2/HER-2 oncogenic signaling Normal mitogenic signaling (left) and Erb-2 (and presumably HER-2) signaling (right) is mediated by Cyclin D1 or other D-type Cyclins through activation of either Cdk4/6 kinases, kinase-independent interaction with Cdk4/6 and p27Kip1, or interaction with other targets. Boxes at the bottom indicate the main biological consequences of each pathway. Cancer Cell 2006 9, 2-4DOI: (10.1016/j.ccr.2005.12.026) Copyright © 2006 Elsevier Inc. Terms and Conditions