Selfish DNA: Homing Endonucleases Find a Home David R. Edgell  Current Biology  Volume 19, Issue 3, Pages R115-R117 (February 2009) DOI: 10.1016/j.cub.2008.12.019 Copyright © 2009 Elsevier Ltd Terms and Conditions

Figure 1 Endonuclease-mediated mobility pathways and evolution of mobile group I introns. Schematic of three distinct homing pathways mediated by homing endonucleases that occur in co-infections between donor (endonuclease containing) and recipient (endonuclease lacking) phage. In each pathway, cleavage by the homing endonuclease (green dumbbells) in the recipient genome leads to DNA repair and recombination using the donor phage genome as a template. For simplicity, not all recombination products are shown in the recipient phage. In the case of collaborative homing, invasion of a group I intron by a free-standing endonuclease would be facilitated by illegitimate recombination, creating a mobile group I intron as proposed by Shub and co-workers [14,15]. Current Biology 2009 19, R115-R117DOI: (10.1016/j.cub.2008.12.019) Copyright © 2009 Elsevier Ltd Terms and Conditions