Volume 142, Issue 7, Pages (June 2012)

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Volume 142, Issue 7, Pages 1414-1416 (June 2012) Self-Renewal of Tumor-Initiating Cells: What's New About Hepatocellular Carcinoma? Anna Alisi Gastroenterology Volume 142, Issue 7, Pages 1414-1416 (June 2012) DOI: 10.1053/j.gastro.2012.04.037 Copyright © 2012 AGA Institute Terms and Conditions

Figure 1 Proposed model for liver T-IC–mediated hepatocarcinogenesis. Tumorigenicity and metastatic potential of liver T-ICs depend on the acquisition of specific traits: switch from quiescence to proliferation, self-renewal, differentiation ability, and infiltrative capacity that may lead to development of a chemoresistant and metastatic HCC. As explained in the text, several cell-surface markers, pathways and fate-determining regulatory factors may be involved in the acquisition of these traits. Gastroenterology 2012 142, 1414-1416DOI: (10.1053/j.gastro.2012.04.037) Copyright © 2012 AGA Institute Terms and Conditions