EGLN inhibition by FG-4592 reduces toxicity and enables definitive radiation treatment of pancreatic cancer. EGLN inhibition by FG-4592 reduces toxicity.

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EGLN inhibition by FG-4592 reduces toxicity and enables definitive radiation treatment of pancreatic cancer. EGLN inhibition by FG-4592 reduces toxicity and enables definitive radiation treatment of pancreatic cancer. Distribution of all causes of morbidity leading to death for vehicle alone (A), FG-4592 alone (B), >65Gy RT + Vehicle (C), and >65 Gy RT + FG-4592 (D). E and F, An example of intestinal bleeding (arrows) observed at necropsy in a mouse that received 75Gy of fractionated radiation without radioprotection (E; scale bar, 1 cm), with histopathologic correlation (F) from the same mouse showing edema, hemorrhage, and leukocytic infiltration. G, Representative histopathology of a jejunal section at necropsy from mouse treated with full dose ablative RT with FG-4592 for radioprotection. The major lesions identified were edema, focal crypt necrosis, and leukocytic infiltration. Tara N. Fujimoto et al. Cancer Res 2019;79:2327-2338 ©2019 by American Association for Cancer Research