Optogenetically stimulated Aβ fibers induce pain-like behaviors after PNI. A, B, Withdrawal score by light (A) and paw withdrawal threshold by von Frey.

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From: Spinal IL-33/ST2 Signaling Contributes to Neuropathic Pain via Neuronal CaMKII–CREB and Astroglial JAK2–STAT3 Cascades in Mice Anesthes. 2015;123(5):

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Optogenetically stimulated Aβ fibers induce pain-like behaviors after PNI. A, B, Withdrawal score by light (A) and paw withdrawal threshold by von Frey filaments (B) of W-TChR2V4 rats before and after PNI (n = 9 rats; ****p < 0.0001, ***p < 0.001, **p < 0.0... Optogenetically stimulated Aβ fibers induce pain-like behaviors after PNI. A, B, Withdrawal score by light (A) and paw withdrawal threshold by von Frey filaments (B) of W-TChR2V4 rats before and after PNI (n = 9 rats; ****p < 0.0001, ***p < 0.001, **p < 0.01, *p < 0.05 vs value on day 0, repeated-measures one-way ANOVA with post hoc Dunnett’s test). C, Effect of intrathecal morphine (15 µg; left) or pregabalin (10 µg; right) on light-induced withdrawal responses of W-TChR2V4 rats on 14 d post-PNI [n = 7 rats; ****p < 0.0001, ***p < 0.001 vs value before PNI (Pre), paired t test; ###p < 0.001 vs value at 0 min, repeated-measures one-way ANOVA with post hoc Dunnett’s test]. D, Paw withdrawal threshold of W-TChR2V4 rats in von Frey testing on 14 d post-PNI before and after intrathecal morphine (15 µg; left) or pregabalin [10 µg; right; n = 6 rats, ***p < 0.001 vs value before PNI (Pre), paired t test; ####p < 0.0001, ##p < 0.01 vs value at 0 min, repeated-measures one-way ANOVA with post hoc Dunnett’s test]. Values represent mean ± SEM. Ryoichi Tashima et al. eNeuro 2018;5:ENEURO.0450-17.2018 ©2018 by Society for Neuroscience