Immunohistochemical and immunogluorescence analysis of renal biopsies showing significant C5b-9, C4d and C3c deposition but almost absent Bb deposition in the glomeruli. Immunohistochemical and immunogluorescence analysis of renal biopsies showing significant C5b-9, C4d and C3c deposition but almost absent Bb deposition in the glomeruli. Immunohistochemical (A–C) and direct immunofluorescence analysis (D) of glomerular deposition of complement fractions C5b-9, C4d, Bb, and C3c in patients with ANCA-associated renal vasculitis. Lucio Manenti et al. CJASN 2015;10:2143-2151 ©2015 by American Society of Nephrology