Transcripts enriched and depleted in NB TICs compared with SKPs and other tumor tissues. Transcripts enriched and depleted in NB TICs compared with SKPs.

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Transcripts enriched and depleted in NB TICs compared with SKPs and other tumor tissues. Transcripts enriched and depleted in NB TICs compared with SKPs and other tumor tissues. Differentially expressed genes were identified using exon array and RNA sequencing data from SKPs and NB TICs. An equivalent analysis was conducted using RNA sequencing data from NB TICs and other cancers. Venn diagrams summarize the overlap of the results from the three analyses for upregulated (A) and downregulated (B) genes. RNA sequencing expression profiles of 321 TIC-enriched (red column) and 819 TIC-depleted transcripts (blue column) in NB TICs, SKPs, and other cancer libraries are plotted as a heat map with genes as rows and samples as columns (C). The NB TIC libraries are labeled with the “TIC” prefix, and the tissue identities of the remaining libraries are explained in the Supplementary Table S1. Olena Morozova et al. Clin Cancer Res 2010;16:4572-4582 ©2010 by American Association for Cancer Research