Volume 76, Issue 2, Pages 145-148 (July 2009) The link between obesity and albuminuria: adiponectin and podocyte dysfunction  Kumar Sharma  Kidney International  Volume 76, Issue 2, Pages 145-148 (July 2009) DOI: 10.1038/ki.2009.137 Copyright © 2009 International Society of Nephrology Terms and Conditions

Figure 1 Potential links between adiposity, kidney response, and cardiovascular disease. With increasing fat mass, visceral adipocytes decrease the production of circulating adiponectin and increase the production of adipokines that enhance insulin resistance. The lower adiponectin levels lead to impaired podocyte function, possibly because of increased podocyte NADPH oxidase. Podocyte dysfunction will lead to albuminuria and increased levels of hydrogen peroxide in the urine. The increased production of hydrogen peroxide from renal NADPH oxidase could potentially cause hydrogen peroxide to enter the circulation, contributing to the systemic inflammation that accompanies low-grade albuminuria. Kidney International 2009 76, 145-148DOI: (10.1038/ki.2009.137) Copyright © 2009 International Society of Nephrology Terms and Conditions