PHF10 acts as a transcriptional repressor.

Slides:

Advertisements

Similar presentations

HMGA2 is a SUMOylation target.

Advertisements

Homocysteine inhibits endothelial cell growth via DNA hypomethylation of the cyclin Agene by Md S. Jamaluddin, Irene Chen, Fan Yang, Xiaohua Jiang, Michael.

Vrtn functions as a transcriptional repressor.

Implications of somatic mutations in the AML1 gene in radiation-associated and therapy-related myelodysplastic syndrome/acute myeloid leukemia by Hironori.

Runx genes are direct targets of Scl/Tal1 in the yolk sac and fetal liver by Josette-Renée Landry, Sarah Kinston, Kathy Knezevic, Marella F.T.R. de Bruijn,

by Wu-Guo Deng, Ying Zhu, and Kenneth K. Wu

Transcriptional activities of c-MYB and A-MYB fusion proteins.

ATF5 transactivates Egr-1 via the ATF5CON sites in the Egr-1 promoter.

MUC1 Oncoprotein Stabilizes and Activates Estrogen Receptor α

MUC1 Oncoprotein Stabilizes and Activates Estrogen Receptor α

Volume 11, Issue 9, Pages (June 2015)

Truncated protein isoforms of CD19 provide proliferative advantage while evading CART-19. Truncated protein isoforms of CD19 provide proliferative advantage.

SUMO-1 Modification Represses Sp3 Transcriptional Activation and Modulates Its Subnuclear Localization Sarah Ross, Jennifer L Best, Leonard I Zon, Grace.

Hua Gao, Yue Sun, Yalan Wu, Bing Luan, Yaya Wang, Bin Qu, Gang Pei

Fusion of PALB2 to the BRCT repeats of BRCA1 mediates the assembly of DNA damage foci by PALB2 and RAD51 in BRCA1-deficient cells. Fusion of PALB2 to the.

SIRT1 is downregulated in human gastric cancer (GC).

The microtubule-binding region of RECQL4 is required for chromosome alignment. The microtubule-binding region of RECQL4 is required for chromosome alignment.

Curcumin-generated ROS activates Chk1 and Chk2 kinases.

Accumulation of ubiquitinated MDM2 following PN treatment requires the PIKK ATM. A, Western blots of nuclear extract proteins from ZR-75-1 cells treated.

GA blocks HIF activity and reduces HIF target expression.

Immunohistochemical detection of 8-OHdG by use of the 1F7 monoclonal antibody in oligomer-treated PC3 prostate cancer cells. a, control untreated peripheral.

Effects of PS-341 on human pancreatic cancer cells in vitro.

VP16-E2 is a more potent transcriptional activator than Gal4-VP16.

Gramicidin A (GA) decreases HIF protein expression in RCC cells.

Variation in dUTPase expression in cell lines.

Key functional sites of SPINDLIN1 could be phosphorylated by Aurora-A.

T-VISA is robust in ovarian cancer cell lines.

CDCP1 is required for invadopodia formation and ECM degradation by human breast cancer cells. CDCP1 is required for invadopodia formation and ECM degradation.

Epigenetic regulation of p16INK4a in human gastric cancer.

A, ATP production by PC3 prostate cancer cells after treatment with oligonucleotide/Lipofectin complexes. a, ATP production by PC3 prostate cancer cells.

CDCP1 colocalizes and interacts with MT1-MMP.

Mapping the Pirh2 and p73 interaction sites.

Activation of CHOP and DR5 by DIM-C-pPhtBu.

Interaction of MAPJD with E-box sequence of the RIOK1 gene.

CDDO-Me induces apoptosis independent of Bcl-2 level as well as p53 status in human NSCLC cells. CDDO-Me induces apoptosis independent of Bcl-2 level as.

SATB2-AS1 repressed Snail transcription depending on SATB2-mediated recruitment of HDAC1. SATB2-AS1 repressed Snail transcription depending on SATB2-mediated.

MTB1 Antagonizes MYC2 for DNA Binding.

Overexpression of Pim kinases contributes to increased protein translation in resistant cells through controlling cap-independent translation. Overexpression.

Mitotic catastrophe symptoms caused by curcumin are followed by apoptosis. Mitotic catastrophe symptoms caused by curcumin are followed by apoptosis. A.

Flow cytometric analysis of single pMHCI-IgG binding and pMHCI delivery to hIGF-1R+ NIH3T3 and MCSP+ UCLA-SO-M14 cells target cells at different concentrations.

A, top, representative Western blot for Ku70 in MCF7 cell extracts following siRNA knockdown of Ku70, compared with siRNA control. A, top, representative.

Effect of G9a on the expression of GSH synthesis enzymes.

EMT gene expression patterns of M-Wnt and E-Wnt cells in vitro and in vivo. EMT gene expression patterns of M-Wnt and E-Wnt cells in vitro and in vivo.

DNA damage-induced RPA foci in asynchronous cells labeled with BUdR.

Histone modification status at the Tβ4 promoter and at the protein level in the HuH7 sublines. Histone modification status at the Tβ4 promoter and at the.

Curcumin suppresses the expression of antiapoptotic proteins in multiple myeloma cells. Curcumin suppresses the expression of antiapoptotic proteins in.

Functional assessment of NF-κB activation in SKBR3 cells.

KPT-9274 shows specificity for attenuation of PAK4 targets preferentially in RCC cells. KPT-9274 shows specificity for attenuation of PAK4 targets preferentially.

LY induces replication stress and depletes the pool of available RPA2 for binding to DNA. HeLa cells were treated with 0.4% DMSO, 100 nmol/L LY

CDCP1 localizes to intracellular vesicles containing lipid rafts.

Colony formation of K-562 cells after 24 h (upper panel) or 48 h (lower panel) exposure to ErPC3 (20 μm) and ASO-bcr (10 μm), respectively. Colony formation.

Effect of GSK3β inhibition on cell survival and proliferation of glioblastoma cells. Effect of GSK3β inhibition on cell survival and proliferation of glioblastoma.

Incorporation of the TSTA system into a single plasmid.

Effect of coapplication of dexrazoxane and doxorubicin on DSB formation, TOP2A protein level, and apoptosis. Effect of coapplication of dexrazoxane and.

Ki-67 expression in M31- and H3-treated tumors (A) and respective Ki-67 labeling indices in the two groups of tumors (B). Ki-67 expression in M31- and.

Pirh2 represses p73-dependent transactivation.

PTPH1 depends on its catalytic activity to increase ER nuclear accumulation and to enhance breast cancer sensitivity to TAM. A, effects of PTPH1 and PTPH1/DA.

Volume 11, Issue 9, Pages (June 2015)

Purified Vpr induces double-strand breaks in vitro.

N1 decoys differently inhibit ligand-induced NOTCH signaling.

Effect of bevacizumab on the proliferation of A2780 cells.

The interaction of PALB2 with BRCA1 is required for the assembly of PALB2, BRCA2, and RAD51 nuclear foci. The interaction of PALB2 with BRCA1 is required.

Effect of dexamethasone on PCDGF/GP88 mRNA and protein expressions and effect of PCDGF/GP88 on dexamethasone-induced cell death. Effect of dexamethasone.

Effect of BCAA on the progression of cell cycle, expression of p21CIP1, and induction of apoptosis in HepG2 cells in the presence and absence of visfatin.

Influence of minocycline on TGF-β1 expression and TGF-β1–induced NF-кB activation in ovarian cancer cells. Influence of minocycline on TGF-β1 expression.

AXL-on tumors are heterogeneous for AXL expression and EdU incorporation. AXL-on tumors are heterogeneous for AXL expression and EdU incorporation. A,

RRC1 Interacts with phyB and Colocalizes in Nuclear Photobodies.

An NH2-terminal domain of PALB2, distinct from the BRCA2-interacting domain of PALB2, mediates interaction with BRCA1 and assembly of PALB2 nuclear foci.

MED25 and JAZ7 Compete to Interact with MYC2.

MTB1 Interacts with MYC2 and Disrupts MED25-MYC2 Interaction.

Presentation transcript:

PHF10 acts as a transcriptional repressor. PHF10 acts as a transcriptional repressor. A, top, localization of PHF10 in gastric cancer cells. A coverslip seeded with SGC7901 cells was double stained with PHF10 antibody to permit detection of PHF10 (a) and phalloidin to permit detection of actin (b). A DNA-binding dye, DAPI, was used to counterstain the DNA (c). In SGC7901s cells, PHF10 accumulated in nuclear domains that colocalize with dense regions of DAPI staining (d), indicating association with chromatin. Middle, histogram showing transcriptional activity analysis of PHF10 fusion proteins in 293T cells. Columns, mean of three experiments; bars, SD. *, P < 0.05 versus control, cotransfection of pCMV-BD-V and pLexA-VP16. Diagram at the bottom depicts the mechanisms underlying this assay. B, transcriptional activity analysis of full-length and truncated PHF10 fusion proteins in 293T cells. Columns, mean of three experiments; bars, SD. *, P < 0.05 versus cotransfection of pCMV-BD-V and pL8G5 luciferase, which was used as control. Min Wei et al. Mol Cancer Ther 2010;9:1764-1774 ©2010 by American Association for Cancer Research