Increased neutrophil priming and sensitization before commencing cardiopulmonary bypass in cardiac surgical patients Y.John Gu, MD, PhD, Pieter Schoen,

Slides:

Advertisements

Similar presentations

The effect of cardiotomy suction on the brain injury marker S100β after cardiopulmonary bypass Russell E Anderson, MD, PhD, Lars-Olof Hansson, MD, PhD,

Advertisements

Relative Changes in Cerebral Blood Flow During Cardiac Operations Using Xenon-133 Clearance Versus Transcranial Doppler Sonography Uday H Trivedi, FRCS,

Stress-Dose Corticosteroid Versus Placebo in Neonatal Cardiac Operations: A Randomized Controlled Trial Pertti K. Suominen, MD, PhD, Juho Keski-Nisula,

Cardiac surgery with cardiopulmonary bypass in patients with type II heparin-induced thrombocytopenia Abdellah Aouifi, MD, Pascale Blanc, MD, Vincent.

Changes in cysteinyl leukotrienes during and after cardiac surgery with cardiopulmonary bypass in patients with and without chronic obstructive pulmonary.

Cytokine release and neutrophil activation are not prevented by heparin-coated circuits and aprotinin administration Jean-Olivier Defraigne, MD, PhD,

Reduction of the Inflammatory Response in Patients Undergoing Minimally Invasive Coronary Artery Bypass Grafting Y.John Gu, Massimo A Mariani, Willem.

The Myocardial Protective Effects of a Moderate-Potassium Blood Cardioplegia in Pediatric Cardiac Surgery: A Randomized Controlled Trial Yang Liu, MD,

Attenuation of Changes in Leukocyte Surface Markers and Complement Activation With Heparin-Coated Cardiopulmonary Bypass Oddvar Moen, MD, Kolbjørn Høgåsen,

Fibrinogen Levels After Cardiac Surgical Procedures: Association With Postoperative Bleeding, Trigger Values, and Target Values Marco Ranucci, MD, Valeria.

Relative Changes in Cerebral Blood Flow During Cardiac Operations Using Xenon-133 Clearance Versus Transcranial Doppler Sonography Uday H Trivedi, FRCS,

A Closed Perfusion System With Heparin Coating and Centrifugal Pump Improves Cardiopulmonary Bypass Biocompatibility in Elderly Patients Lena Lindholm,

Reduction of heparin dose is not beneficial to platelet function

P. W. Boonstra, MD, PhD, Y. J. Gu, MD, PhD, C. Akkerman, BSc, J

Continuous pulmonary perfusion during cardiopulmonary bypass prevents lung injury in infants Takaaki Suzuki, MD, Toyoki Fukuda, MD, Tsutomu Ito, MD,

James L Zellner, MD, Scott B Kribbs, BS, B

Bashir M Matata, PhD, Andrzej W Sosnowski, MD, Manuel Galiñanes

Intraoperative Hemoglobin Levels and Transfusion Independently Predict Stroke After Cardiac Operations Zainab S. Bahrainwala, BS, Maura A. Grega, RN,

Assessment of heparin anticoagulation: comparison of two commercially available methods Hanne I Flom-Halvorsen, PhD, Eivind Øvrum, MD, PhD, Michel Abdelnoor,

Leukocyte depletion during cardiac operation: a new approach through the venous bypass circuit Y.John Gu, MD, PhD, A.J de Vries, MD, Paulien Vos, Piet.

Effects of Depletion of Leukocytes and Platelets on Cardiac Dysfunction After Cardiopulmonary Bypass Yukio Chiba, Kouichi Morioka, Ryusuke Muraoka, Akio.

Aprotinin in pediatric cardiac operations: a benefit in complex malformations and with high-dose regimen only Thierry P Carrel, MD, Mike Schwanda, MD,

Susanne Lison, MD, Michael Spannagl, MD, PhD, Wulf Dietrich, MD, PhD

Oxidative Stress and Atrial Fibrillation After Cardiac Surgery: A Case-Control Study Basel Ramlawi, MD, MMSc, Hasan Otu, PhD, Shigetoshi Mieno, MD, Munir.

Hedi H Schreurs, Marianne J Wijers, Y

Definition of postoperative bleeding in children undergoing cardiac surgery with cardiopulmonary bypass: One size doesn't fit all David Faraoni, MD,

The influence of leukocyte filtration during cardiopulmonary bypass on postoperative lung function: A clinical study Tomislav Mihaljevic, MDa, Martin.

Changes in glomerular filtration rate after cardiac surgery with cardiopulmonary bypass in patients with mild preoperative renal dysfunction B.G. Loef,

Synergistic Immunosuppression Caused by High-Dose Methylprednisolone and Cardiopulmonary Bypass Hisanori Mayumi, MD, Qui-Wei Zhang, MD, Atsuhiro Nakashima,

An Analysis of Oxygen Consumption and Oxygen Delivery in Euthermic Infants After Cardiopulmonary Bypass With Modified Ultrafiltration Jia Li, MD, PhD,

Central venous catheter use in low-risk coronary artery bypass grafting Robert D Stewart, MD, Triffin Psyhojos, MD, Stephen J Lahey, MD, Sidney Levitsky,

Ricardo H Boks, BS, Lex A van Herwerden, MD, PhD, Johanna J

Influence of Mechanical Cell Salvage on Red Blood Cell Aggregation, Deformability, and 2,3-Diphosphoglycerate in Patients Undergoing Cardiac Surgery With.

Comparison of bovine and porcine heparin in heparin antibody formation after cardiac surgery John L Francis, PhD, George J Palmer, MD, Rebecca Moroose,

The effects of heparin and extracorporeal circulation on platelet counts and platelet microaggregation during cardiopulmonary bypass Elijah W. Muriithi,

Comparative effects of propofol versus fentanyl on cerebral oxygenation state during normothermic cardiopulmonary bypass and postoperative cognitive dysfunction

Stress-Dose Corticosteroid Versus Placebo in Neonatal Cardiac Operations: A Randomized Controlled Trial Pertti K. Suominen, MD, PhD, Juho Keski-Nisula,

Changes in cysteinyl leukotrienes during and after cardiac surgery with cardiopulmonary bypass in patients with and without chronic obstructive pulmonary.

Clinical performance and biocompatibility of poly(2-methoxyethylacrylate)—coated extracorporeal circuits Serdar Gunaydin, MD, Bora Farsak, MD, Mustafa.

Cardiac surgery with cardiopulmonary bypass in patients with type II heparin-induced thrombocytopenia Abdellah Aouifi, MD, Pascale Blanc, MD, Vincent.

One-stage coronary and abdominal aortic operation with or without cardiopulmonary bypass: early and midterm follow-up Raimondo Ascione, MD, Gabriele.

Coronary surgery without cardiotomy suction and autotransfusion reduces the postoperative systemic inflammatory response Martin Westerberg, MD, Anders.

Platelet-leukocyte activation and modulation of adhesion receptors in pediatric patients with congenital heart disease undergoing cardiopulmonary bypass

Plasma levels of interleukin-8 and expression of interleukin-8 receptors on circulating neutrophils and monocytes after cardiopulmonary bypass in children

Benjamin C. Sun, MD, Timothy A. Dickinson, CCP, Eric A

Red Blood Cell Transfusion Is Associated With Troponin Release After Elective Off- Pump Coronary Artery Bypass Surgery Fausto Biancari, MD, PhD, Eeva-Maija.

Anticoagulation with bivalirudin during cardiopulmonary bypass in cardiac surgery Julio C Vasquez, MD, Anna Vichiendilokkul, PharmD, Syed Mahmood, MD,

Platelet and Neutrophil Activation During Cardiac Surgical Procedures: Impact of Cardiopulmonary Bypass David S Morse, David Adams, Barbarajean Magnani

Monocyte Tissue Factor Expression and Ongoing Complement Generation in Ventricular Assist Device Patients Carl R. Wilhelm, Julianne Ristich, Robert L.

Heparin-induced thrombocytopenia: bovine versus porcine heparin in cardiopulmonary bypass surgery Barbara A Konkle, MD, Thomas L Bauer, MD, Gowthami.

Inflammatory Mediators in Adults Undergoing Cardiopulmonary Bypass: Comparison of Centrifugal and Roller Pumps Saeed Ashraf, John Butler, Yi Tian, Dahlia.

Time course of proinflammatory and anti-inflammatory responses after cardiac operation: monocyte HLA-DR expression Y.John Gu, MD, PhD, Willem van Oeveren,

Protection of the human heart with ischemic preconditioning during cardiac surgery: role of cardiopulmonary bypass Sudip Ghosh, MD, Manuel Galiñanes,

Preoperative Intraaortic Balloon Pump Enhances Cardiac Performance and Improves the Outcome of Redo CABG Jan T. Christenson, MD, PhD, Pierre Badel, MD,

Aprotinin Enhances the Endogenous Release of Interleukin-10 After Cardiac Operations Gary E Hill, Robert P Diego, Alfred H Stammers, Suzanne M Huffman,

Effect of Nitric Oxide Gas on Platelets During Open Heart Operations

Generation of platelet-derived microparticles in patients undergoing cardiac surgery is not affected by complement activation Jeanette M van den Goor,

Grethe Bergseth, BS, John D

Robert R Lazzara, MD, Francis E Kidwell, BS

Successful use of argatroban as a heparin substitute during cardiopulmonary bypass: heparin-induced thrombocytopenia in a high-risk cardiac surgical patient

Factors influencing intensive care unit length of stay after surgery for acute aortic dissection type A Daniel Hoefer, MD, Elfriede Ruttmann, MD, Markus.

Cerebral microemboli during cardiopulmonary bypass: increased emboli during perfusionist interventions Ruth L Taylor, MSc, Michael A Borger, MD, Richard.

The Impact of New Technology on Cardiothoracic Surgical Practice

Neutrophil CD11b upregulation during cardiopulmonary bypass is associated with postoperative renal injury Christine S Rinder, MD, Manuel Fontes, MD,

Leukocytosis and Increased Risk of Atrial Fibrillation After General Thoracic Surgery David Amar, MD, Anuj Goenka, BS, Hao Zhang, MD, Bernard Park, MD,

Karl A. Bocchieri, BS, CCP, S. Jacob Scheinerman, MD, L

Safety of low hematocrits during cardiopulmonary bypass

Y.John Gu, MD, PhD, Piet W. Boonstra, MD, PhD, Willem van Oeveren, PhD

A randomized trial of antithrombin concentrate for treatment of heparin resistance Mathew R Williams, MD, Alyssa B D’Ambra, BA, James R Beck, Talia B.

Thrombophilic Variables Do Not Increase the Generation or Procoagulant Activity of Thrombin During Cardiopulmonary Bypass Peter Raivio, MD, Jari Petäjä,

Presentation transcript:

Increased neutrophil priming and sensitization before commencing cardiopulmonary bypass in cardiac surgical patients Y.John Gu, MD, PhD, Pieter Schoen, PhD, Izaak Tigchelaar, BS, Bart G Loef, MD, Tjark Ebels, MD, PhD, Andrew J Rankin, PhD, Willem van Oeveren, PhD The Annals of Thoracic Surgery Volume 74, Issue 4, Pages 1173-1179 (October 2002) DOI: 10.1016/S0003-4975(02)03822-5

Fig 1 Circulating levels of leukocytes, granulocytes, and elastase in venous samples taken from 20 cardiac surgical patients with cardiopulmonary bypass (CPB). Data are expressed as mean ± standard error. ∗p < 0.05 and ∗∗p < 0.01 compared with T1. (T1 = before operation; T2 = prior to CPB; T3 = 30 min on CPB; T4 = end of CPB; T5 = 2 h arriving intensive unit; T6 = postoperative day 1; T7 = day 2; T8 = day 7.) The Annals of Thoracic Surgery 2002 74, 1173-1179DOI: (10.1016/S0003-4975(02)03822-5)

Fig 2 The primability of neutrophils in vitro stimulated by cytochalasin B (CytoB) before, during, and after cardiac operations with cardiopulmonary bypass (CPB) (n = 20). Data are comparisons (ratio) of elastase concentrations between the CytoB-stimulated and unstimulated samples and are expressed as mean ± standard error based on comparison of each individual patient. (T1 = before operation; T2 = prior to CPB; T3 = 30 min on CPB; T4 = end of CPB; T5 = 2 h arriving intensive unit; T6 = postoperative day 1; T7 = day 2; T8 = day 7.) The Annals of Thoracic Surgery 2002 74, 1173-1179DOI: (10.1016/S0003-4975(02)03822-5)

Fig 3 (A) Platelet-activating factor-induced release of elastase in whole blood primed with cytochalasin B. (B) N-formyl-methionyl-leucyl-phenylalanine-induced release of elastase in whole blood primed with cytochalasin B. Elastase concentrations are corrected for the sample granulocyte count (ng/mL per million granulocytes). Blood samples were taken from venous samples taken before, during, and after cardiac operations with cardiopulmonary bypass (CPB). Data are expressed as mean ± standard error. ∗p < 0.05 and ∗∗p < 0.01 compared with T1. (T1 = before operation; T2 = prior to CPB; T3 = 30 min on CPB; T4 = end of CPB; T5 = 2 h arriving intensive unit; T6 = postoperative day 1; T7 = day 2; T8 = day 7.) The Annals of Thoracic Surgery 2002 74, 1173-1179DOI: (10.1016/S0003-4975(02)03822-5)