• Kaplan-Meier analyses of (A) time-to-recurrence (TTR) for the subgroup of patients with high-risk melanoma who had relapsed (n=82), (B) recurrence-free survival (RFS) of the whole cohort (n=173), (C) TTR analysed by substage at initial diagnosis of high-risk melanoma and (D) TTR of Stage II versus Stage III high-risk melanoma. • Kaplan-Meier analyses of (A) time-to-recurrence (TTR) for the subgroup of patients with high-risk melanoma who had relapsed (n=82), (B) recurrence-free survival (RFS) of the whole cohort (n=173), (C) TTR analysed by substage at initial diagnosis of high-risk melanoma and (D) TTR of Stage II versus Stage III high-risk melanoma. Kok Haw Jonathan Lim et al. ESMO Open 2018;3:e000317 Copyright © European Society for Medical Oncology. All rights reserved.