Activation of Wnt signaling pathway in trastuzumab-resistant cell lines. Activation of Wnt signaling pathway in trastuzumab-resistant cell lines. A, bar.

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Activation of Wnt signaling pathway in trastuzumab-resistant cell lines. Activation of Wnt signaling pathway in trastuzumab-resistant cell lines. A, bar graph representing significantly upregulated (dark bars) or downregulated (gray bars) mRNA of Wnt pathway genes in SKBR3/100-8 compared with SKBR3 analyzed by microarray analysis. B, bar graph of regulated Wnt/β-catenin pathway signaling in SKBR3/100-8 (dark bars) and BT474/100-2 (open bars) compared with SKBR3 and BT474 analyzed by specific Wnt/β-catenin mRNA array. The relative level of each indicated gene was adjusted with glyceraldehyde-3-phosphate dehydrogenase (GAPDH), and each bar indicates mean fold change and SD from 4 determinations. Yanyuan Wu et al. Mol Cancer Res 2012;10:1597-1606 ©2012 by American Association for Cancer Research