Effect of miRNA mimic on platinum sensitivity.

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Fig. 2. Cellular response to FolamiRs in vitro.

Presentation transcript:

Effect of miRNA mimic on platinum sensitivity. Effect of miRNA mimic on platinum sensitivity. A, miR-193b* mimic effect on cellular sensitivity to carboplatin 24 hours posttransfection. Data shown in this figure is derived from a randomly selected LCL samples (GM07056). B, miR-193b* mimic effect on cellular sensitivity to cisplatin 24 hours posttransfection. Data shown in this figure is derived from a randomly selected LCL samples (GM07056). C, miR-193b* overexpression effect on carboplatin sensitivity in an OVCAR-3 cell line 48 hours posttransfection. Dash line represents the growth inhibition curve after transfecting cells with miR-193b* mimic, whereas the solid line represents the growth inhibition curve of the same cell line treated with a scramble control. A two-way ANOVA method was used to compare the cellular growth inhibition effect by platinum after treating the cells with either miR-193b* mimic or scramble control. Dana Ziliak et al. Mol Cancer Ther 2012;11:2054-2061 ©2012 by American Association for Cancer Research