Schematic drawing of PAH crisis and contributing factors.

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Presentation transcript:

Schematic drawing of PAH crisis and contributing factors. Schematic drawing of PAH crisis and contributing factors. Pulmonary hypertensive crisis develops with an acute increase of PAP. This leads to an increase in RV pressure and volume causing a shift of the interventricular septum towards the left side and reducing LV volume. Filling pressures of ventricles rise, compensatory tachycardia and the drop in systemic blood pressure compromise coronary perfusion pressure and flow, leading to low cardiac output and metabolic acidosis. Furthermore, the increase in PAP causes decreased pulmonary blood flow and airway obstruction related to arterial distension of the smaller intrapulmonary arteries and lung oedema. Consequently dead space ventilation increases; together with a mismatch of pulmonary ventilation and perfusion this causes hypoxia and respiratory acidosis. PAH, pulmonary arterial hypertension; RVEDV, RV end-diastolic volume; RVEDP, RV end-diastolic pressure; LVEDP, LV end-diastolic pressure; V/Q, pulmonary ventilation and perfusion; PAH, pulmonary arterial hypertension; PAP, pulmonary artery pressure; PVR, pulmonary vascular resistance; CHD, congenital heart disease; NO, nitric oxide; CPB, cardiopulmonary bypass; LR-Shunt, left-to-right shunt; PBF, pulmonary blood flow. Michael Kaestner et al. Heart 2016;102:ii57-ii66 Copyright © BMJ Publishing Group Ltd & British Cardiovascular Society. All rights reserved.