Fig. 4 Differential histone modifications at promoters in various brain cell populations. Differential histone modifications at promoters in various brain.

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Fig. 4 Differential histone modifications at promoters in various brain cell populations. Differential histone modifications at promoters in various brain cell populations. The data under analysis were generated with 1000 nuclei per assay using samples from mouse M3. (A) Pearson correlations of SurfaceChIP-seq signals in promoter regions across various cell populations. Each set of data has two replicates (R1 and R2). (B) Heatmap of all differentially marked promoters identified by DESeq2 (adjusted P < 0.05) between PNeuN+ and CNeuN+. (C) Venn diagram of bivalent promoters in PNeuN+ and CNeuN+. (D) Hive plots showing the proportions of bivalent promoters specific to PNeuN+ (or CNeuN+) being H3K4me3-marked, H3K27me3-marked, or not marked in the other neuronal population. Ribbons are proportional to the number of promoters changing marking. (E) The change in histone modification state is associated with gene expression change. *P < 10−4; **P < 10−15. (F) Pair-wise comparisons of H3K4me3 level, H3K27me3 level, and gene expression [log10(FPKM), measured by mRNA-seq] at various genes across PNeuN+ and CNeuN+ populations. The differential histone modifications (adjusted P < 0.05) and differentially expressed (fold change > 4) genes are shown as colored points in these. Selected genes associated with synapse GO term are labeled. Sai Ma et al. Sci Adv 2018;4:eaar8187 Copyright © 2018 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).