Expression of XCR1 in normal ovarian surface epithelium and the IOSE and borderline EOC cell lines. Expression of XCR1 in normal ovarian surface epithelium.

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Expression of XCR1 in normal ovarian surface epithelium and the IOSE and borderline EOC cell lines. Expression of XCR1 in normal ovarian surface epithelium and the IOSE and borderline EOC cell lines. A, a representative image of XCR1 expression in a specimen from a normal ovary. Black arrow indicates the ovarian surface epithelium in the normal ovary. Brown – XCR1, blue – hemotoxylin. Images were generated using an Aperio ScanScope digital slide scanner. Magnification: × 10. B, expression of XCR1 in the indicated IOSE cell line T1074 was detected by flow cytometry analysis and immunofluorescent staining. Cell surface expression of XCR1 in IOSE was analyzed by flow cytometry analysis. Solid thick line – XCR1 expression, solid thin line – negative control (secondary antibody only). Images (× 40) shown are representative of at least 3 independent experiments. The fluorescent signal from XCR1 staining (red) was overlaid with DAPI staining (blue). C, Cell surface expression of XCR1 in the borderline EOC cell lines was detected with flow cytometry analysis. Solid thick line – XCR1 expression, solid thin line – negative control (secondary antibody only). Representative of at least 3 independent experiments. Mijung Kim et al. Mol Cancer Res 2012;10:1419-1429 ©2012 by American Association for Cancer Research