Effects of placebo or carvedilol CR on 24-hour mean systolic blood pressure and diastolic blood pressure obtained by ambulatory monitoring in hypertensive patients after 6 weeks of treatment. Effects of placebo or carvedilol CR on 24-hour mean systolic blood pressure and diastolic blood pressure obtained by ambulatory monitoring in hypertensive patients after 6 weeks of treatment. Values shown are ± SE. SBP inferences are based on an ad hoc analysis. *P ≤ 0.001 for dose-related trend tests for change from baseline in mean diastolic and systolic blood pressure for all carvedilol CR doses with placebo. DBP, diastolic blood pressure; SBP, systolic blood pressure. Reprinted with permission from Ref. 66. Janet B. McGill Clin Diabetes 2009;27:36-46 ©2009 by American Diabetes Association