Microarray analysis of global gene expression profiles of PC-3 and derivative cell lines. Microarray analysis of global gene expression profiles of PC-3.

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Microarray analysis of global gene expression profiles of PC-3 and derivative cell lines. Microarray analysis of global gene expression profiles of PC-3 and derivative cell lines. A, a schematic diagram describing the generation of the PC-3 derivative cell lines using the in vitro transendothelial migration model or the in vivo murine metastatic colonization model. The relationship between the parental PC-3 cell line and all derivative cell lines is depicted. Derivative cell lines selected for gene expression microarray analysis are indicated by boxes. B, PCA of global gene expression profiles of PC-3 and derivative cell lines. C, gene expression levels of 60 well-known splicing factors. The six splicing factors with significant expression differences between PC-3 and derivative cell lines are highlighted. D, real-time qPCR results of six splicing factors. GAPDH was used as the reference gene. Relative gene expression level was normalized to PC-3 cells. Error bar, SEM of technical triplicates. Zhi-xiang Lu et al. Mol Cancer Res 2015;13:305-318 ©2015 by American Association for Cancer Research