Fig. 4 Effects of hematopoietic restoration of TLR9 on adipose tissue inflammation and insulin resistance. Effects of hematopoietic restoration of TLR9.

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Fig. 4 Effects of hematopoietic restoration of TLR9 on adipose tissue inflammation and insulin resistance. Effects of hematopoietic restoration of TLR9 on adipose tissue inflammation and insulin resistance. (A) Mac3 staining of epididymal fat obtained from BM chimeric mice (n = 7). Scale bar, 100 μm. (B) Quantitative RT-PCR analysis of inflammatory gene expression in epididymal fat obtained from BM chimeric mice (n = 7). (C) Western blot analysis of the phosphorylation of IκBα in epididymal fat obtained from BM chimeric mice (n = 6 to 7). (D) Results of insulin tolerance test (0.75 U/kg) of BM chimeric mice (n = 7 to 8). (E) Quantitative RT-PCR analysis of epididymal fat obtained from BM chimeric mice for genes related to insulin sensitivity (n = 7). All experiments in this figure were performed using samples obtained from mice fed a high-fat diet (HFD) for 12 weeks. †P = 0.06, *P < 0.05, **P < 0.01, and ***P < 0.001. All values are means ± SEM. Sachiko Nishimoto et al. Sci Adv 2016;2:e1501332 Copyright © 2016, The Authors