Effect of anti-cyCD79b (10D10) and anti-cyCD79b (10D10)-MCC-DM1 on cytokine levels in cynomolgus monkeys. Effect of anti-cyCD79b (10D10) and anti-cyCD79b.

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Effect of anti-cyCD79b (10D10) and anti-cyCD79b (10D10)-MCC-DM1 on cytokine levels in cynomolgus monkeys. Effect of anti-cyCD79b (10D10) and anti-cyCD79b (10D10)-MCC-DM1 on cytokine levels in cynomolgus monkeys. Plasma cytokine levels were quantified for 23 cytokines to determine if anti-CD79b antibodies induced B-cell receptor signaling and systemic cytokine release. Data is shown for each animal (4/group) at 4 timepoints (pre-dose, and 5 min, 6 hr, and 24 hr post-dose) for IL-1ra, IL-6, IL-8, IL-12/23 (p40), IL-15, GM-CSF, MCP-1, MIP-1α, MIP-1β, sCD40L, and TGF-α. Data not shown for IL-1β, IL-2, IL-4, IL-5, IL-10, IL-13, IL-17, IL-18, IFN-γ, G-CSF, TNF-α, and VEGF (signal < 2pg/ml limit of detection). Bing Zheng et al. Mol Cancer Ther 2009;8:2937-2946 ©2009 by American Association for Cancer Research