Comparison of variant associations from previous reports and results from the KP GWAS meta-analysis for 105 known prostate cancer risk SNPs. Plotted values.

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Comparison of variant associations from previous reports and results from the KP GWAS meta-analysis for 105 known prostate cancer risk SNPs. Plotted values are the log odds ratios from the previous and current studies. Comparison of variant associations from previous reports and results from the KP GWAS meta-analysis for 105 known prostate cancer risk SNPs. Plotted values are the log odds ratios from the previous and current studies. Error lines denote the 95% CIs for the respective studies, colored by chromosome. Blue line is the diagonal, showing generally high correlation between the previous and new odds ratios. The SNP rs116041037 appears to be an African-American–specific SNP and is an outlier so we left it off of the plot to more easily view the other points; the SNP had a previous OR = 2.45 (95% CI, 1.65–3.62), and KP OR = 2.67 (1.96, 3.64). Thomas J. Hoffmann et al. Cancer Discovery 2015;5:878-891 ©2015 by American Association for Cancer Research