Fig. 2 NDR2-deficient mice are more vulnerable to RNA viral infection.

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Fig. 5 Correlation of RNA expression and protein abundance.

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Fig. 2 NDR2-deficient mice are more vulnerable to RNA viral infection. NDR2-deficient mice are more vulnerable to RNA viral infection. (A) ELISA of IFN-β, IL-6, and TNF-α in serum obtained from 8-week-old male NDR2f/f and Lysm+NDR2f/f mice (n = 6 per group) 12 hours after intraperitoneal infection with VSV [1 × 107 plaque-forming units (PFU) g−1]. (B) VSV titers by TCID50 assay in spleens, lungs, and livers from mice in (A). (C) Pathology of NDR2f/f and Lysm+NDR2f/f mice in response to VSV infection. Hematoxylin and eosin staining of lung sections from mice in (A). Scale bars, 200 μm (for 4×) and 50 μm (for 20×). (D) Neutrophil (CD11b+Gr-1+) infiltration in murine bronchoalveolar lavage fluid (BALF) from mice treated with intraperitoneal injections of PBS (n = 3) or VSV (1 × 107 PFU g−1 and n = 3) was assessed 12 hours after injection. (E) Survival of 8-week-old male NDR2f/f and Lysm+NDR2f/f mice administered VSV (1 × 108 PFU g−1) via tail intravenous injection (n = 8 per group; Wilcoxon test). (F) Survival curve for 8-week-old male NDR2f/f (n = 8) and Lysm+NDR2f/f (n = 9) mice infected with H1N1 virus (2 × 103 PFU per mouse) by intranasal inoculation (Wilcoxon test). (G) Real-time PCR analysis of flu-M mRNA of lungs from 8-week-old male NDR2f/f and Lysm+NDR2f/f mice 4 days after intranasal inoculation with H1N1 virus (2 × 103 PFU per mouse) (n = 6 per group). Data are means ± SD and are representative of three independent experiments. Student’s t test was used for statistical calculation. *P < 0.05, **P < 0.01, and ***P < 0.001. Zhiyong Liu et al. Sci Adv 2019;5:eaav0163 Copyright © 2019 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).