BRCA1 del (ex 9-12) haplotype.

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Presentation transcript:

BRCA1 del (ex 9-12) haplotype. BRCA1 del (ex 9-12) haplotype. The haplotype was determined from the mother (2025-14) and daughter (2025-1) pair (in bold type). No determination was made for marker D17S1327 as the genotype is equivalent in both mother and daughter. Dash, deleted marker D17S1323 in the mutant allele. For the other four cases, a genotype was established. All the individuals carrying the mutation carried the alleles associated with the haplotype, suggesting that this is a founder mutation. Jeffrey N. Weitzel et al. Cancer Epidemiol Biomarkers Prev 2007;16:1615-1620 ©2007 by American Association for Cancer Research